Roughly one in three Americans today report that drugs have been a source of trouble for their family. After his son Brian took his own life amid a struggle with addiction, Gary Mendell WG94 founded Shatterproof to transform treatment and change how the public views substance-use disorders.

Inspired by his loss, Mendell aims to end the stigma in America by shifting awareness toward a better comprehension of the realities of the disease and the current treatment system. Shatterproof is spurring change among health-care companies, communities, and legislatures — efforts that earlier this year garnered the nonprofit $5 million from philanthropist MacKenzie Scott to expand its work.

Read more from the Watchlist.